In Search of Innovative Solutions

fellow with chem-hood

The pediatric surgery research effort is dedicated to helping improve the health of children. The problems of our small patients also become the motivation for investigators in the basic sciences to study mechanisms of disease and to develop new therapies to cure previously untreatable birth defects. Creating innovative solutions requires successful collaboration of diverse biological and physical science groups, and we continue to cultivate partnerships with many other outstanding research groups. The breadth of our research program spans basic science and translational research to innovation & device development to novel clinical therapies in the area of fetal and pediatric surgery. 

Our clinical and basic science research programs have grown remarkably in productivity and funding in the past five years. We currently have more than $4 million in grants and awards for our faculty and fellows-a tremendous achievement after having limited funding for several years.

Find out more about the UCSF Division of Pediatric Surgery

Find out more about the UCSF Fetal Treatment Center

Recent Publications

Li R, Beebe T, Jen N, Yu F, Takabe W, Harrison M, Cao H, Lee J, Yang H, Han P, Wang K, Shimizu H, Chen J, Lien CL, Chi NC, Hsiai TK
Shear stress-activated Wnt-angiopoietin-2 signaling recapitulates vascular repair in zebrafish embryos.
Arteriosclerosis, thrombosis, and vascular biology, Oct-01-2014; 3410: 2268-75.  Epub 2014 Aug 21.
Derderian SC, Togarrati PP, King C, Moradi PW, Reynaud D, Czechowicz A, Weissman IL, MacKenzie TC
In utero depletion of fetal hematopoietic stem cells improves engraftment after neonatal transplantation in mice.
Blood, Aug-07-2014; 1246: 973-80.  Epub 2014 May 30.
Vu LT, Vittinghoff E, Nobuhara KK, Farmer DL, Lee H
Surgical site infections in neonates and infants: is antibiotic prophylaxis needed for longer than 24 h?.
Pediatric surgery international, Jun-01-2014; 306: 587-92.  Epub 2014 May 9.
Jeanty C, Derderian SC, Mackenzie TC
Maternal-fetal cellular trafficking: clinical implications and consequences.
Current opinion in pediatrics, Jun-01-2014; 263: 377-82.
Derderian SC, Trivedi S, Farrell J, Keller RL, Rand L, Goldstein R, Feldstein VA, Hirose S, MacKenzie TC
Outcomes of fetal intervention for primary hydrothorax.
Journal of pediatric surgery, Jun-01-2014; 496: 900-3; discussion 903-4.  Epub 2014 Jan 31.
Sanchez Rodriguez R, Pauli ML, Neuhaus IM, Yu SS, Arron ST, Harris HW, Yang SH, Anthony BA, Sverdrup FM, Krow-Lucal E, MacKenzie TC, Johnson DS, Meyer EH, Löhr A, Hsu A, Koo J, Liao W, Gupta R, Debbaneh MG, Butler D, Huynh M, Levin EC, Leon A, Hoffman WY, McGrath MH, Alvarado MD, Ludwig CH, Truong HA, Maurano MM, Gratz IK, Abbas AK, Rosenblum MD
Memory regulatory T cells reside in human skin.
The Journal of clinical investigation, Mar-03-2014; 1243: 1027-36.  Epub 2014 Feb 10.
Wegorzewska M, Nijagal A, Wong CM, Le T, Lescano N, Tang Q, MacKenzie TC
Fetal intervention increases maternal T cell awareness of the foreign conceptus and can lead to immune-mediated fetal demise.
Journal of immunology (Baltimore, Md. : 1950), Feb-15-2014; 1924: 1938-45.  Epub 2014 Jan 15.
Fleck S, Bautista G, Keating SM, Lee TH, Keller RL, Moon-Grady AJ, Gonzales K, Norris PJ, Busch MP, Kim CJ, Romero R, Lee H, Miniati D, MacKenzie TC
Fetal production of growth factors and inflammatory mediators predicts pulmonary hypertension in congenital diaphragmatic hernia.
Pediatric research, Sep-01-2013; 743: 290-8.  Epub 2013 Jun 14.
Shue E, Bolouri M, Jelin EB, Vu L, Bratton B, Cedars E, Yoke L, Byrne F, Hirose S, Feldstein V, Miniati D, Lee H
Tumor metrics and morphology predict poor prognosis in prenatally diagnosed sacrococcygeal teratoma: a 25-year experience at a single institution.
Journal of pediatric surgery, Jun-01-2013; 486: 1225-31.
Nijagal A, Derderian C, Le T, Jarvis E, Nguyen L, Tang Q, Mackenzie TC
Direct and indirect antigen presentation lead to deletion of donor-specific T cells after in utero hematopoietic cell transplantation in mice.
Blood, May-30-2013; 12122: 4595-602.  Epub 2013 Apr 22.
Nijagal A, MacKenzie TC
Clinical implications of maternal-fetal cellular trafficking.
Seminars in pediatric surgery, Feb-01-2013; 221: 62-5.
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