Miniati Lab

Doug Miniati, M.D.Doug Miniati, M.D.

Assistant Professor of Surgery

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Neonates with congenital diaphragmatic hernia (CDH) represent a fascinating challenge to those who are involved in their care. Great strides have been made to improve our perinatal and perioperative care for these patients, leading to increased survival. However, a wide spectrum of disease severity exists, from the few, who are cured with a single procedure, to the majority, who suffer long-term sequelae related pulmonary insufficiency and gastrointestinal dysfunction. Much remains to be understood regarding both normal and abnormal lung development and response to various stimuli, and more importantly, regarding the advancement of new and effective therapeutic strategies for patients with CDH.

The Miniati lab focuses on 1) furthering our understanding of the mechanisms of CDH-associated lung hypoplasia in both teratogenic and genetic mouse models, and 2) developing prenatal pharmacologic treatments and in utero mechanical means to promote optimal lung function in the ovine CDH model. Other developing areas of interest include the human genetics of CDH and continued long-term outcomes analyses of children in our multidisciplinary CDH clinic. Through collaborations with colleagues in the Lung Biology Center, the UC Berkeley/UCSF Bioengineering Program, and the divisions of neonatology and pediatric intensive care, we are gaining more insight into how this disease occurs and how to treat it, ultimately leading to improved quality of life for both patients and their families.

Current lab members

  • Eric Jelin, post-doctoral fellow, NIH NRSA
  • Jianfeng Wu, Staff Research Associate
  • Mozziyar Etemadi, M.D.-Ph.D. student
  • Sam Schecter, post-doctoral fellow

Former lab members

  • Jennifer Ng, medical student
  • Scott Grubb, engineering student
  • Traci Fitzharris, engineering student
  • Monica Sevilla, engineering student

Collaborators

  • Jeffrey Fineman, M.D., Professor of Pediatrics, Director of Research Training in Pediatric Critical Care Medicine, CVRI Senior Investigator
  • Shuvo Roy, Ph.D., Associate Professor of Bioengineering and Therapeutic Sciences, Director of Biomedical Microdevices Laboratory
  • Philip Ballard, M.D., Professor of Pediatrics, Division of Neonatology
  • Roberta Keller, M.D., Assistant Professor of Pediatrics, Co-Director of Multidisciplinary CDH Long-term Follow-up Clinic
  • Rong Wang, Ph.D., Associate Professor of Surgery, Director of Laboratory for Accelerated Vascular Research

Funding sources

  • NIH NHBLI
  • American Pediatric Surgical Association Foundation
  • American Lung Association
  • UCSF Academic Senate
  • UCSF REAC

Publications:

Miniati D, Jelin EB, Ng J, Wu J, Carlson TR, Wu X, Looney MR, Wang RA. Constitutively active endothelial Notch4 causes lung arteriovenous shunts in mice. Am J Physiol Lung Cell Mol Physiol, Feb/2010; 298(2):L169-77.

Jancelewicz T, Vu LT, Keller RL, Bratton B, Lee H, Farmer D, Harrison M, Miniati D, Mackenzie T, Hirose S, Nobuhara K. Long-term surgical outcomes in congenital diaphragmatic hernia: observations from a single institution. J Pediatr Surg, Jan/2010;45(1):155-60; discussion 160.

Miniati D: Pulmonary vascular remodeling. In Congenital Diaphragmatic Hernia-Current Status, Lally K, ed., Semin Pediatr Surg 2007; 16(2):80-7.

Miniati DN, Chintagumpala M, Langston C, Dishop MK, Olutoye OO, Nuchtern JG, Cass DL:Prenatal diagnosis and outcome of children with pleuropulmonary blastoma. J Ped Surg 2006; 41(1):66-71.

 

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